| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of 6-methoxy- -1H-benzotriazole-5-carboxamide of the formula (I) <EMI ID=0.328 HE=27 WI=60 TI=CHI> where R means ethyl or cyclopropylmethyl; R means hydrogen atom, methyl or ethyl; n = 1, 2 or 3 and wavy line <EMI ID=0.329 HE=3 WI=18 TI=CHI> means that configuration of substituents at carbon atom bound with N-atom in amide group is (RS), (R) or (S), or pharmaceutically acceptable acid-additive salts. Invention describes also methods of their synthesis, pharmaceutical compositions containing the compound of the formula (I) or its pharmaceutically acceptable acid-additive salt and new intermediate compounds. Compounds show the simultaneous an antivomiting activity and activity enhancing the contractile capability of gastroenteric tract. Except for, they show the low depressant activity with respect to the central nervous system and therefore are useful for prophylaxis and treatment of functional disorders of gastroenteric tract associated with different diseases and therapeutic treatment as an agent enhancing the contractile capability of gastroenteric tract. EFFECT: improved method of synthesis of new compounds, valuable curative properties. 11 cl, 7 tbl, 4 dwg, 38 ex |
