ANTIGEN ZYGOTE CONSISTING OF PRESERVATIVE LIPOPOLYSACCHARIDE OF GRAM NEGATIVE BACTERIUM

摘要

PROBLEM TO BE SOLVED: To obtain an antigen zygote inducing not only an immunogenic response against a specified species of a gram negative bacterium but also a cross reaction immune response against a different strain or a different serum type from that of a gram negative bacterium belonging to a specified genus, preferably against a gram negative bacterium of a different genus, and a vaccine containing the antigen zygote. SOLUTION: The antigen zygote comprising a carrier protein bound by a covalent bond to a preservative part consisting of an inside core part and a lipid A part of lipopolysaccharide of a gram negative bacterium and a vaccine containing the antigen zygote. This antigen zygote induces a cross reaction immune response against a different strain of the gram negative bacterium, and preferably, against a gram negative bacterium of a different genus.