Recombinant poxvirus-calicivirus rabbit hemorrhagic disease virus (RHDV) compositions and uses

摘要

Attenuated recombinant viruses containing DNA encoding a calicivirus antigen such as a RHDV antigen, e.g., a capsid gene, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. The DNA from the viruses can be used for probes or for primers.