发明名称 |
PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR: A TOOL FOR DETECTION, DIAGNOSIS, PROGNOSIS, AND TREATMENT OF CANCER |
摘要 |
The expression and subcellular localization of peripheral-type benzodiazepine receptors (PBR) is shown in this application to correlate with the metastatic potential of cells, and increased cell proliferation. Inhibition of PBR expression, function or stability results in a decrease in cell proliferation. Compositions and methods for regulating and/or monitoring PBR and its expression are useful for the detection, diagnosis, prognosis and treatment of solid tumors, in particular, breast cancer. |
申请公布号 |
WO9949316(A3) |
申请公布日期 |
1999.11.11 |
申请号 |
WO1999US06515 |
申请日期 |
1999.03.25 |
申请人 |
GEORGETOWN UNIVERSITY MEDICAL CENTER;PAPADOPOULOS, VASSILIOS;CULTY, MARTINE |
发明人 |
PAPADOPOULOS, VASSILIOS;CULTY, MARTINE |
分类号 |
A61K31/711;A61K39/395;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C07K14/705;C07K16/28;C12N5/10;C12N15/09;C12Q1/02;C12Q1/48;C12Q1/68;G01N33/574;G01N33/68 |
主分类号 |
A61K31/711 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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