| 发明名称 |
FAP ALPHA-SPECIFIC ANTIBODY WITH IMPROVED PRODUCIBILITY |
| 摘要 |
Recombinant antibody proteins are provided that specifically bind fibroblast activation protein alpha (FAP.alpha.) and comprise framework modifications resulting in the improved producibility in host cells. The invention also relates to the use of said antibodies for diagnostic and therapeutic purpose s and methods of producing said antibodies.
|
| 申请公布号 |
CA2327586(A1) |
申请公布日期 |
1999.11.11 |
| 申请号 |
CA19992327586 |
申请日期 |
1999.04.22 |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
LEGER, OLIVIER;SALDANHA, JOSE;PARK, JOHN EDWARD;GARIN-CHESA, PILAR;BAMBERGER, UWE;RETTIG, WOLFGANG J. |
| 分类号 |
G01N33/574;A61K38/00;A61K39/395;A61K47/48;A61K49/00;A61K51/10;A61P35/00;C07K16/18;C07K16/40;C07K16/46;C07K19/00;C12N5/10;C12N15/09;C12N15/13;C12N15/62;C12N15/85;C12P21/02;C12Q1/02;G01N33/577;(IPC1-7):C12N15/13 |
主分类号 |
G01N33/574 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
