| 摘要 |
A process for preparing compounds represented by general formula (X), comprising the steps of: saponifying a (2S,3R)-4-hydroxy-2,3-epoxybutanoic acid derivative; regioselectively opening the epoxy ring of the resultant derivative to obtain an open-ring derivative; protecting the amino group of the derivative; lactonizing the protected derivative; reducing the lactone derivative; protecting the 1- and 2-hydroxy groups of the reduced derivative; thioetherifying the protected derivative; removing the protective groups of the thioetherified derivative; and selectively chlorinating the primary hydroxyl group of the diol derivative; and novel intermediate compounds obtained in the course of the production of the compounds (X). The compounds (X) are useful as a key intermediate of the compound (XI) useful as an HIV protease inhibitor. |
