| 发明名称 |
Bacterial nitroreductase for the reduction of CB1954 and analogues thereof to a cytotoxic form |
| 摘要 |
A prodrug of the formula (I): where R1 is a group such that the compound R1NH2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): a prodrug of the formula (II): where R2 is a group such that the compound R2OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.
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| 申请公布号 |
US5977065(A) |
申请公布日期 |
1999.11.02 |
| 申请号 |
US19980087855 |
申请日期 |
1998.06.01 |
| 申请人 |
CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED |
发明人 |
ANLEZARK, GILLIAN;MELTON, ROGER;SHERWOOD, ROGER;CONNORS, THOMAS;FRIEDLOS, FRANK;JARMAN, MICHAEL;KNOX, RICHARD;MAUGER, ANTHONY;SPRINGER, CAROLINE JOY |
| 分类号 |
C12N9/12;A61K38/00;C07C219/34;C07C271/18;C07D203/14;C07D487/14;C07H15/252;C07H19/048;C07K7/06;C12N9/02;C12N15/00;C12N15/09;C12N15/53;C12P17/10;C12P21/08;C12R1/01;C12R1/07;C12R1/19;G01N33/53;G01N33/573;(IPC1-7):A61K38/00;A61K38/12;C07K5/00;C07K7/00 |
主分类号 |
C12N9/12 |
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