| 摘要 |
<p>PROBLEM TO BE SOLVED: To efficiently obtain the subject compound useful as a diagnostic reagent for complications of diabetes and kindney failure by hydrolyzing a specific compound. SOLUTION: This pyridinium compound shown by formula III is obtained by hydrolyzing a compound shown by formula I (Ac is an acyl; and R is a lower alkyl) in a solvent (e.g. methanol) under an alkaline condition with, e.g. lithium methoxide, to produce a compound shown by formula II, and by hydrolyzing, under heating as required, the produced compound under and an acidic condition with, e.g. 6N hydrochloric acid, preferably without isolating it. The compound shown by formula I is obtained by reacting glucose penta-acetate with a cysteine derivative shown by formula IV in the presence of tin tetrachloride to produce a glucose-cysteine derivative shown by formula V, and by eliminating an Fmoc protective group from the derivative. Fmoc in the compound shown by formula IV has a protective group having a structure shown by formula VI.</p> |
