Anthelmintic milbemycins and avermectins

摘要

Novel compounds of formula (I): wherein R1 is hydrogen or optionally protected hydroxy; R2 is alkoxy, optionally protected hydroxy, oxo or optionally O-substituted oximino; R3 is hydrogen, optionally protected hydroxy,or a group 4'-( alpha -L-oleandrosyl)- alpha -L-oleandrosyloxy or alpha -L-oleandrosyloxy wherein the terminal hydroxy group is optionally protected; R4, R5, R6 and R7 are the same or different and each is hydrogen or an organic radical; and R8 is an optionally substituted amino or imino group such as optionally O-substituted oxyimino, optionally N-substituted hydrazone, or optionally N-substituted semicarbazone; are useful in the treatment of helminthiasis in humans and animals.