Process for preparing 6-0-monoesters of castanospermine

摘要

The present invention relates to a process for preparing a compound of formula (I): wherein R is C1-C10 alkyl, phenyl or substituted phenyl, comprising treating a compound of formula (II): with bis(tributyltin) oxide in an organic solvent selected from the group consisting of o-xylene, m-xylene, p-xylene and mixed xylenes; and subsequently treating the reaction mixture with a compound of formula (III): wherein X is halogen and R is defined as above.