发明名称 |
Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity |
摘要 |
This invention provides compounds displaying NGF agonist activity, wherein the compounds comprise a multimer of a sequence of amino acid residues or biologically functional equivalents thereof, the sequence being substantially homologous to residues 29-38 of NGF, residues 43-47 of NGF or residues 92-97 of NGF. Preferably, the multimer is a cyclic dimer wherein the monomeric amino acid sequences are linked to each other by disulfide bridges. This invention also provides methods and compositions for the treatment of disorders involving NGF-responsive cells, by administering an effective amount of the multimeric NGF agonists of this invention to an individual suffering from such disorder.
|
申请公布号 |
US5958875(A) |
申请公布日期 |
1999.09.28 |
申请号 |
US19960623690 |
申请日期 |
1996.03.29 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LONGO, FRANK M.;MANTHORPE, MARSTON |
分类号 |
C07K14/48;(IPC1-7):A61K38/12;C07K5/12 |
主分类号 |
C07K14/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|