摘要 |
FIELD: organic chemistry. SUBSTANCE: invention relates to a new compound of the general formula (I) <EMI ID=0.545 HE=36 WI=69 TI=CHI> and its pharmaceutically acceptable salts and a method of synthesis of these derivatives and a pharmaceutical composition showing an antiviral activity and containing these derivatives as an active component where R<SB>1</SB>,R<SB>2</SB> and R<SB>3</SB> mean independently hydrogen, halogen atom, C<SB>1</SB>-C<SB>5</SB>-alkyl; Z means oxygen, sulfur atom and carbonyl group; X means oxygen atom; n = 1-2 and (sub)cycloalk(en)yl means: <EMI ID=0.546 HE=18 WI=21 TI=CHI> or <EMI ID=0.547 HE=15 WI=21 TI=CHI> where <EMI ID=0.548 HE=18 WI=21 TI=CHI> means <EMI ID=0.549 HE=18 WI=72 TI=CHI> or <EMI ID=0.550 HE=18 WI=21 TI=CHI> where R<SB>4</SB> and R<SB>5</SB> mean independently hydrogen atom, hydroxymethyl, hydroxymethyl protected by the substituted silyl-group. EFFECT: new nucleoside derivatives, antiviral activity, improved method of synthesis. 4 cl, 1 tbl, 55 ex
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