| 摘要 |
New recombinant nucleic acid (I) comprises a promoter; one or more NRSE (neuron restrictive silencer element) sequences and a therapeutic gene (II), arranged such that (II) is controlled by the promoter and this, in turn, is controlled by the NRSE sequences. Independent claims are also included for the following: (a) vectors containing (I); (b) defective recombinant virus (A) containing a gene under control of a promoter and NRSE sequences; (c) cells containing (I), the vector or virus; (d) composition containing (I), the vector or virus; (e) chimeric promoter consisting of a ubiquitous promoter and one or more NRSE sequences. ACTIVITY : Antineurodegenerative; anticancer; antioxidant. MECHANISM OF ACTION : Selective suppression of gene expression in non-neuronal cells. |
