发明名称 |
POLYKETIDES AND THEIR SYNTHESIS |
摘要 |
The present invention provides an extended polyketide synthase gene assembly comprising a loading module and a plurality of extension modules wherein a second nucleic acid portion, encoding at least one extension module, has been inserted into a first nucleic acid portion encoding the loading module and at least one, and preferably a plurality, of extension modules. Such extended genes are useful in the production of novel macrolides of larger size than the natural product, for example 16-membered ring macrolides instead of 14membered ring macrolides.
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申请公布号 |
CA2318365(A1) |
申请公布日期 |
1999.07.22 |
申请号 |
CA19992318365 |
申请日期 |
1999.01.14 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
LEADLAY, PETER FRANCIS;BUSS, ANTONY DAVID;STAUNTON, JAMES;ROWE, CHRISTINE JANET;WILKINSON, BARRIE;BOHM, INES UTE |
分类号 |
C12N15/09;C07D493/08;C12N1/21;C12N15/52;C12P19/62;(IPC1-7):C12N15/52;C07D311/00;C07D321/00;C12N15/76 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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