发明名称 |
Hematopoietic cytokine receptor |
摘要 |
Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular ligand-binding domain of a cell-surface receptor that is expressed at high levels in lymphoid tissue, including B-cells and T-cells. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo.
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申请公布号 |
US5925735(A) |
申请公布日期 |
1999.07.20 |
申请号 |
US19980073594 |
申请日期 |
1998.05.06 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
BAUMGARTNER, JAMES W.;FOSTER, DONALD C.;GRANT, FRANK J.;SPRECHER, CINDY A. |
分类号 |
C12N15/09;A61K38/00;A61P37/02;C07K14/715;C12N5/10;C12N15/12;(IPC1-7):A61K38/16 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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