发明名称 |
TAXANE DERIVATIVES |
摘要 |
Taxane derivatives represented by general formula (1) or salts thereof and drugs containing the same as the active ingredient wherein A1 represents (a) (wherein R1 represents H or optionally substituted alkyl) or (b) (wherein R2 represents amino, mono- or dialkylamino, piperidino, pyrrolidino or morpholino); X represents H, alkoxycarbonyl or benzoyl; Y represents H or trialkylsilyl; A2 represents furyl, alkylfuryl, alkyl or fluorophenyl; Ac represents acetyl; and Bz represents benzoyl. These compounds are excellent in solubility in water and antitumor activity.
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申请公布号 |
CA2314071(A1) |
申请公布日期 |
1999.07.01 |
申请号 |
CA19982314071 |
申请日期 |
1998.12.16 |
申请人 |
KABUSHIKI KAISHA YAKULT HONSHA |
发明人 |
SHIMIZU, HIDEAKI;OGAWA, TAKANORI;SAWADA, SEIGO;ABE, ATSUHIRO;NAGATA, HIROSHI |
分类号 |
C07D305/14;C07D405/12;C07D405/14;C07D407/12;(IPC1-7):C07D305/14;C07D405/10;C07D409/10;C07D413/14;A61K31/445;A61K31/495 |
主分类号 |
C07D305/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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