| 摘要 |
PURPOSE:To provide the title inhibitory agent useful for removing or mitigating the rejection in the transplantation of a variety of organs, containing, as active ingredient, cholera toxin B subunit. CONSTITUTION:The objective inhibitory agent containing, as active ingredient, cholera toxin B subunit, a protein with a molecular weight of ca. 58000. The present inhibitory agent will be administered prior to organ transplantation or simultaneously therewith (if needed, in several portions), pref. through a non-transintestinal route such as the vein, peritoneal cavity or muscle. For the toxin B subunit, any one which has been produced through Vibrio cholerae or by genetic engineering means can be used. Escherichia coli enterotoxin B subunit having similar amino acid structure to that for said toxin B subunit has virtually the same effect as that for said toxin B subunit ; therefore, can be used in a similar way. |
