New tetracyclic pyrido-indole derivatives

摘要

Tetracyclic pyrido3,4-bindole derivatives of formula (I) are new: A+B = O; or A = H or OH and B = H; C+D = O or C = H or OH and D = H, provided that ar least one of A+B and C+D = O; R1+R2 = a bond and R7 = a group of formula (ii): R8-R12 = H, halogen, OH, CN, 1-4C alkyl or 1-4C alkoxy; or R1, R2 = H and R7 = (ii), or R1 = H and CR2R7 = a 5-7C ring; R3-R6 = H or 1-4C alkoxy; X = O or NR13; R13 = H or a group of formula (iii): R14 = -(CH2)n-NR15-(CH2)m-CHR16-(CH2)p-CHR17-(CH2)m-NR18-(CH2)n-; n = 2-3; m = 0 or 2; p = 0-3; R15 and R18 = Me or R15+R18 = CH2CH2 and R16 and R17 = H when m and p = 0, or R15+R16 = CH2CH2 and R17+R18 = CH2CH2 when m = 2.