发明名称 |
Synthetic glucagon binding proteins |
摘要 |
A synthetic human glucagon (hGlu) binding protein designated hGlu DELTA 252-259 binding protein is cloned, expressed and used in an in vitro assay to screen for compounds that bind to the synthetic binding protein, including compounds that specifically stimulate or inhibit the binding of glucagon to the synthetic receptor. The invention includes the assay, the synthetic binding protein used in the assay, DNA encoding the synthetic binding protein, cells expressing the synthetic binding protein, and compounds identified through the use of the synthetic binding protein.
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申请公布号 |
US5889167(A) |
申请公布日期 |
1999.03.30 |
申请号 |
US19970859873 |
申请日期 |
1997.05.21 |
申请人 |
MERCK & CO., INC. |
发明人 |
CASCIERI, MARGARET A.;CHICCHI, GARY A.;GRAZIANO, MICHAEL P.;HEY, PATRICIA J. |
分类号 |
C07K14/605;(IPC1-7):C12N15/10;C12N5/10;C07K14/705 |
主分类号 |
C07K14/605 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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