METHOD OF ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY ACTIVE SUBSTITUTED DERIVATIVES OF 5,6-DIHYDRO-2H-PYRANE-2-ONE

摘要

FIELD: organic chemistry and technology. SUBSTANCE: invention relates to a new catalytic method of synthesis of optically active compounds of the general formula (I) where R and R mean alkyl that can be broken by oxygen atom at position that is different of alpha- or beta-position, or optionally substituted benzyl; R means hydrogen, lower alkyl, optionally substituted benzyl, -CO-R , -COO-R or -CON-R4@2 where R means lower alkyl or aryl. Compounds are synthesized by asymmetric hydrogenation of compound of the formula (II) where R1,R2,R have values indicated above. Compounds are subjected for asymmetric hydrogenation in the presence of a complex of optically active, preferably atropoisomeric diphosphine ligand, with metal of group VIII. EFFECT: improved and simplified method of synthesis. 7 cl, 2 tbl, 24 ex