| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivative of saccharin of the general formula (I) <EMI ID=0.483 HE=24 WI=69 TI=CHI> where R<SB>1</SB> - lower alkyl; R<SB>2</SB> - B=N-<EMI ID=0.484 HE=6 WI=39 TI=CHI>, -O-, -O-<EMI ID=0.485 HE=6 WI=39 TI=CHI>, -B=N-(2-furanyl) and R - hydroxy(lower)alkoxy-group; B is N-di-(lower)-alkylamino-group; R - phenyl-(lower)-alkyl; p and p' - whole numbers 1 or 2; R<SB>3</SB> is H; X is H or halogen; Y - a group -N=C(Z'')-N(Z'')- or -N=C(R''')-N(R''') where groups R''' together with carbon or nitrogen atoms to that they are bound mean group <EMI ID=0.486 HE=6 WI=15 TI=CHI>; groups Z'' combined with carbon or nitrogen atoms to that they are connected form pyrido-group, or its pharmaceutically acceptable salt that act as inhibitors of proteolytic enzymes and can be used for treatment of patients with emphysema, rheumatic arthritis and pancreatitis. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 7 cl, 5 tbl, 22 ex |
