| 摘要 |
<p>Cyclic compounds represented by general formula (1) A^COOR1, or pharmaceutically acceptable salts thereof, medicinal compositions containing these compounds, and remedies for diabetes containing these compounds wherein A represents, (a), (b), (c) or (d), wherein R2 represents halogenated lower alkyl; R3 represents halogeno or lower alkyl; R4 represents lower alkyl; and R5 represents lower alkyl; and R1 represents hydrogen, lower alkyl, aryl, cycloalkyl or aralkyl. The compounds (1) or pharmaceutically acceptable salts thereof exert excellent hypoglycemic effects in a hyperglycemic state but do not affect blood sugar level in a normal or hypoglycemic state, i.e., showing no serious side effects such as hypoglycemia. Thus, they are useful as remedies for diabetes and preventives for chronic complications of diabetes.</p> |
