发明名称 |
Mutagenized DNA molecules encoding modified subunit a of Cholera-toxin |
摘要 |
The development of subunits and subunit analogs of the cholera exotoxin by recombinant DNA techniques provides vaccine products that can retain their biological activity and immunogenicity, and can confer protection against disease challenge. Genetically-engineered modifications of the subunits result in products that retain immunogenicity, yet are reduced in, or are essentially free of, enzymatic activity associated with toxin reactogenicity.
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申请公布号 |
US5874287(A) |
申请公布日期 |
1999.02.23 |
申请号 |
US19950435605 |
申请日期 |
1995.05.05 |
申请人 |
AMGEN INC.;UNIV SOUTHERN CALIFORNIA |
发明人 |
BURNETTE, W. NEAL;KASLOW, HARVEY R. |
分类号 |
A61K39/106;A61K39/00;A61P31/04;C07K14/00;C07K14/195;C07K14/28;C07K14/41;C07K19/00;C12N1/21;C12N15/09;C12N15/31;C12P21/02;(IPC1-7):C12N1/00;C12N5/10;C12N15/54 |
主分类号 |
A61K39/106 |
代理机构 |
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代理人 |
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地址 |
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