| 摘要 |
<p>The present invention of compounds of formula (I), a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R?1 and R2¿ taken together form a bivalent radical of formula wherein in said bivalent radical one or two hydrogen atoms may be substituted with C¿1-6?alkyl; R?3¿ is hydrogen or halo; R4 is hydrogen or C¿1-6?alkyl; R?5¿ is hydrogen or C¿1-6?alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula -Alk-R?6¿-, Alk-X-R7, -Alk-Y-C(=O)-R9, or -Alk-Y-C(=O)-NR11R12 wherein each Alk is C¿1-12?alkanediyl; and R?6¿ is hydrogen, cyano, C¿1-6?alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ringsystem; R?7¿ is hydrogen, C¿1-6?alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, S, SO2 or NR?8¿; said R8 being hydrogen or C¿1-6?alkyl; R?9¿ is hydrogen, C¿1-6?alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR?10¿ or a direct bond; said R10 being hydrogen, or C¿1-6?alkyl; R?11 and R12¿ each independently are hydrogen, C¿1-6?alkyl, C3-6cycloalkyl, or R?11 and R12¿ combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.</p> |
