发明名称 |
NOVEL THYROID RECEPTOR LIGANDS AND METHOD |
摘要 |
Novel thyroid receptor ligands as provided which have general formula (I) in which: R1 is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 3 carbons or cycloalkyl of 3 to 5 carbons, at least one of R2 and R3 being other than hydrogen; n is an integer from 0 to 4; R4 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid ester thereof, alkenyl carboxylic acid or ester thereof, hydroxy, halogen, cyano, or a phosphonic acid or an ester thereof, or a pharmaceutically acceptable salt thereof. A method for treating diseases associated with metabolism dysfunction or which are dependent on the expression of a T3 regulated gene (such as obesity, hypercholesterolemia, osteoporosis, hypothyroidism and goiter) is also provided.
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申请公布号 |
WO9900353(A1) |
申请公布日期 |
1999.01.07 |
申请号 |
WO1998EP04039 |
申请日期 |
1998.06.26 |
申请人 |
KARO BIO AB;LI, YI-LIN;LIU, YE;HEDFORS, ASA;MALM, JOHAN;MELLIN, CHARLOTTA;ZHANG, MINSHENG |
发明人 |
LI, YI-LIN;LIU, YE;HEDFORS, ASA;MALM, JOHAN;MELLIN, CHARLOTTA;ZHANG, MINSHENG |
分类号 |
A61K31/662;A61K31/085;A61K31/192;A61K31/275;A61P3/00;A61P3/04;A61P3/06;A61P5/14;A61P9/02;A61P9/06;A61P9/10;A61P19/10;A61P25/24;A61P27/06;A61P35/00;C07C41/18;C07C43/295;C07C59/68;C07C65/24;C07C255/37;C07F9/38;C07F9/40;(IPC1-7):C07C59/68;A61K31/19;A61K31/66 |
主分类号 |
A61K31/662 |
代理机构 |
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代理人 |
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