发明名称 |
(Cyanomethylene) phosphoranes as carbonyl 1,1-dipole synthons for use in constructing combinatorial libraries |
摘要 |
The invention is directed to systematic synthetic and testing strategies for alpha -keto acids, esters and amides. The method of synthesis comprises (A) reacting (cyanomethylene)triphenylphosphorane with a carbonyl compound selected from carboxylic acids (RCOOH) and acyl chlorides (RCOCl) to make a cyano keto phosphorane, (B) oxidizing said phosphorane and (C) reacting the oxidized product with a nucleophile (NuH) to make the product alpha -keto acid, ester or amide. Systematic synthesis and testing are achieved by a modular approach in which arrays of molecules are generated by variation of R and Nu.
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申请公布号 |
US5834588(A) |
申请公布日期 |
1998.11.10 |
申请号 |
US19950503070 |
申请日期 |
1995.07.14 |
申请人 |
YALE UNIVERSITY |
发明人 |
WASSERMAN, HARRY H.;HO, WEN-BIN |
分类号 |
C07B61/00;C07C67/39;C07C227/26;C07C229/22;C07C231/14;C07C235/78;C07C269/06;C07C271/22;C07D313/00;C07F9/535;C07K1/04;C07K1/08;(IPC1-7):C07K1/02 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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