| 摘要 |
<p>PCT No. PCT/GB96/00467 Sec. 371 Date Aug. 29, 1997 Sec. 102(e) Date Aug. 29, 1997 PCT Filed Mar. 1, 1996 PCT Pub. No. WO96/26918 PCT Pub. Date Sep. 6, 1996A method for the preparation of a compound of formula (I) <IMAGE> (I) wherein X is hydrogen; Y is (i) a group -CO2R5 wherein R5 is a carboxyl protecting group or (ii) a group -CONR6OR7 wherein R6 is an amino protecting group and R7 is a hydroxyl protecting group; and S1, S2, S3 and S4 each represent covalently bound moieties which are substantially non-reactive with the reaction components (II), (III), or (IV) defined below, which method comprises causing the co-condensation in a liquid organic medium of a carboxylic acid reaction component of formula (II); an aldehyde of formula (IIIA); ammonia; and an isonitrile reaction component of formula (IV): <IMAGE> (II) <IMAGE> (IIIA) <IMAGE> (IV) wherein Y, S1, S2, S3 and S4 are as defined with respect to formula (I).</p> |
