发明名称 |
Methods and compositions for diagnosis and treatment of breast cancer |
摘要 |
The present invention relates to a novel gene, Di12, that is differentially expressed as a 1.35 kb RNA in breast cancer tissues and cell lines, and in several normal tissues. The full length cDNA encodes a protein of 339 amino acids. Antibodies to the gene product were developed to investigate the expression of Di12 in breast cancer cell-lines and tumors. The Di12 protein was found in tissue sections of infiltrating ductal carcinomas (IDCs), but not in benign or normal breast specimens. Di12 wag also present in IDC-breast cancer patient sera, and its expression level increased markedly if IDC was accompanied by lymph node or distal metastases. As IDC constitutes ~70% of breast cancers seen clinically, the level of Di12 expression is useful for diseases diagnosis predicting disease progression and monitoring a therapeutic treatment. |
申请公布号 |
AU6768598(A) |
申请公布日期 |
1998.10.20 |
申请号 |
AU19980067685 |
申请日期 |
1998.03.20 |
申请人 |
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT |
发明人 |
JOHN N VOURNAKIS;ARUN K. SETH;TAKIS S. PAPAS |
分类号 |
A01K67/027;A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;C07K14/47;C07K16/18;C07K19/00;C12N1/21;C12N5/10;C12N15/09;C12P21/02;C12Q1/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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