| 摘要 |
PCT No. PCT/GB93/02281 Sec. 371 Date Jun. 28, 1995 Sec. 102(e) Date Jun. 28, 1995 PCT Filed Nov. 4, 1993 PCT Pub. No. WO94/11354 PCT Pub. Date May 26, 1994The invention relates to tricyclic compounds of formula (I) <IMAGE> (I) wherein R1 is hydrogen, amino, (1-4C)alkyl, (1-4C)alkoxy, hydroxy-(1-4C)alkyl or fluoro-(1-4C)alkyl; R2 is hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, hydroxy-(2-4C)alkyl, halogeno-(2-4C)alkyl or cyano-(1-4C)alkyl; Ar is optionally-substituted phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl; and R3 includes a group of the formula -NHCH(CO2H)-A1-Y1 wherein A1 is (1-6C)alkylene and Y1 is carboxy, tetrazol-5-yl, N-[(1-4C)alkylsulphonyl]carbamoyl, N(phenylsulphonyl)carbamoyl, tetrazol-5-ylthio, tetrazol-5-ylsulphinyl or tetrazol-5-ylsulphonyl; or pharmaceutically-acceptable salts or esters thereof; to processes for their manufacture; to pharmaceutical compositions containing them; and to their use as anti-cancer agents.
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