| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject immunosuppressant not producing a serious side effect and excellent in an immunosuppressive action, especially an antilymphocytic action by including a specific linear saccharide as an active ingredient. SOLUTION: This immunosuppressant contains a thermally treated linear saccharide comprisingβ-1,3-glycoside bonds as an active ingredient. The saccharide preferably comprises a curdlan hydrolysate, especially an acid curdlan hydrolysate using formic acid or the curdlan hydrolysate usingβ-1,3-glucanase, and has a number-average mol.wt. of 340-4000. The thermal treatment is preferably carried out at a temperature of >=80 deg.C in an aqueous solution. Concretely, a 0.5-5.0wt.% curdlan aqueous solution containing an acid in a concentration of 1-85wt.% is subjected to an acid hydrolysis reaction at a temperature of 70-100 deg.C for about 10min.
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