| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for simply producing the subject compound useful as a key intermediate of an medicine, an agrochemical, further a liquid crystal, etc., or an optical purity determining reagent by performing an asymmetric transamination by using a specific organic base as a solvent. SOLUTION: This method for producing an asymmetric primary amine containing fluorine is constituted by dissolving a carbonyl compound containing fluorine and expressed by formula I (Rf of a 1-16C perfluorollakyl; R is a 1-16 alkyl or an aralkyl) preferably in an aromatic hydrocarbon-based solvent such as benzene, toluene and xylene, adding (R)- or (S)-1-phenylethylamine, reforming a dehydration condensation reaction at a room temperature of at a reflex temperature to form a Schiff-base, performing a [1,3] proton shift reaction by adding an organic base such as triethylemine at a temperature not developing a recemization reaction (preferably at a room temperature to approximately 60 deg.C), and performing an asymmetric transamination reaction like by an enzyme, by hydrolyzing the obtained tautiomeric imine by using preferably 2-4N HC1 under a condition not developing the racemization to produce an objective compound expressed by formula II. |
