Liquid phase peptide syntheses of KL-4 pulmonary surfactant
摘要
The invention realtes to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the alpha-carbon.
申请公布号
WO9802461(A3)
申请公布日期
1998.06.11
申请号
WO1997US12163
申请日期
1997.07.11
申请人
ORTHO PHARMACEUTICAL CORPORATION
发明人
ABDEL-MAGID, AHMED, F.;EGGMANN, URS;MARYANOFF, CYNTHIA, ANNE;THALER, ADRIAN;VILLANI, FRANK, J.