PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES

摘要

This application discloses a process for producing 8-[2'-(2(1)-tert-butyl-2H-tetrazol-5-yl) -biphenyl-4-yl-methyl]-2,4-dimethyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (or such a compound wherein a benzyl or p-methoxybenzyl group is present in place of the tert-butyl group) or a salt thereof, said process characterized in (B) transmetallizing bromo[2-[2-(tert-butyl)-2H-tetrazol-5-yl]phenyl]magnesium Grignard reagent with zinc chloride or bromide; and (C) reacting the transmetallized product with 8-[(4-bromophenyl)-methyl]5,8-dihydro-2,4-dimethyl-pyrido[2,3-d]pyrimidin-7(6H-one in the presence of a palladium catalyst to yield the product; wherein throughout the process a benzyl or p-methoxybenzyl group may be present in place of the tert-butyl group.