发明名称 |
Adenoviruses having modified fiber proteins |
摘要 |
PCT No. PCT/US94/09172 Sec. 371 Date Feb. 6, 1996 Sec. 102(e) Date Feb. 6, 1996 PCT Filed Aug. 11, 1994 PCT Pub. No. WO95/05201 PCT Pub. Date Feb. 23, 1995An adenovirus wherein the adenovirus fiber protein includes a ligand which is specific for a receptor located on a desired cell type. The adenovirus may have at least a portion of the adenovirus fiber protein removed and replaced with a ligand which is specific for a receptor located on a desired cell type, or the adenovirus may include a fusion protein of the adenovirus fiber protein and the ligand. Such an adenovirus may also include a gene(s) encoding a therapeutic agent(s) and may be "targeted" in order to deliver such gene(s) to a desired cell type.
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申请公布号 |
US5756086(A) |
申请公布日期 |
1998.05.26 |
申请号 |
US19960591492 |
申请日期 |
1996.02.06 |
申请人 |
GENETIC THERAPY, INC. |
发明人 |
MCCLELLAND, ALAN;STEVENSON, SUSAN C. |
分类号 |
A61K38/00;A61K48/00;C07K14/075;C07K14/475;C07K14/525;C07K14/775;C12N7/04;C12N9/64;C12N15/34;C12N15/861;C12N15/87;(IPC1-7):C12N15/86;C12N15/62 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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