Recombinant single chain antibodies directed against the gp54 cancer marker, composition comprising same and use thereof

摘要

This invention relates to a novel single chain antibody molecules. The starting antibodies from which are derived these molecules are T16 and 48-127. Theses antibodies recognize different epitopes of the gp54 antigen which is expressed at the surface of a plurality of carcinoma cells. Are disclosed: the sequence of the light and heavy chain and of a single chain antibody molecule (scFv) for each antibody. Both scFvs bind gp54-expressing cells, and the immune complexes are internalised by cells. Therapeutic and diagnostic compositions/methods are also disclosed.