RADIOLABELED O-METHYL PHOSPHOTRIESTER AND O-METHYL PHOSPHOROTHIOATE INTERNUCLEOSIDE LINKAGES AND OLIGONUCLEOTIDES CONTAINING THE SAME
摘要
The invention provides oligonucleotides containing methyl phosphotriester linkages and processes for making and methods for using such oligonucleotides. The preparation of radiolabeled oligonucleotides is also disclosed. The radiolabel is a 14C-methyl group attached to an oxygen atom of an internucleoside phosphate group.
申请公布号
WO9805675(A3)
申请公布日期
1998.04.02
申请号
WO1997US13554
申请日期
1997.08.01
申请人
HYBRIDON, INC.
发明人
IYER, RADHAKRISHNAN, P.;DEVLIN, THERESA;HABUS, IVAN;YU, DONG;AGRAWAL, SUDHIR;JOHNSON, SUZANNE, M.