CUSHIONING BEADS AND TABLET COMPRISING THE SAME CAPABLE OF FORMING A SUSPENSION

摘要

Cushioning beads comprising microcrystalline cellulose and a disintegrant (preferably croscarmellose sodium) are disclosed. The cushioning beads are prepared by extrusion-spheronization, followed by freeze-drying. Also disclosed are water-dispersible tablets having high tensile strength, comprising the cushioning beads and biologically active ingredient-loaded beads, wherein optionally, the tablets can contain a viscosity enhancer in the form of separate beads, or as a component of the biologically active ingredient-loaded beads such that viscosity is rapidly generated when the tablets come in contact with water, and a homogeneous suspension is formed, which can be easily swallowed by children and the elderly, with minimal effect on the biologically active ingredient release properties. The tablets are useful for sustained delivery of large doses of biologically active ingredients where swallowing of a large tablet or capsule poses a problem.