| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel compound which is useful in an N-methyl-D-aspartic acid receptor subtype-specific blocker in diseases, for example, an acute neurodegeneration caused by cerebral apoplexy, Alzheimer's disease, Parkinson's disease, Huntington's disease and the like. SOLUTION: This compound is represented by formula I (X is -O-, -NH-, -CH2 -; R<1> -R<4> are H, a halogen, OH, a lower alkylsulfonylamino; R<7> -R<10> are each H, a lower alkyl, a halogen; n is 0, 1), typically 1[2-(4-hydroxy-phenoxy) ethyl]-4-(4-methyl-benzyl)-piprtidine-4-ol. The compound of formula I is prepared by reaction of a compound of formula II with a compound of formula III. |
