发明名称 |
Polymorphic forms I and II of finasteride |
摘要 |
<p>Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17β-carboalkoxy-4-aza-5α-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride.</p><p>Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.</p> |
申请公布号 |
EP0823436(A2) |
申请公布日期 |
1998.02.11 |
申请号 |
EP19970201712 |
申请日期 |
1993.11.12 |
申请人 |
MERCK & CO. INC. |
发明人 |
DOLLING, ULF H.;MOCAULEY, JAMES A.;VARSOLONA, RICHARD J. |
分类号 |
A61K31/58;C07F3/00;C07J73/00;C07J75/00;H04N5/74;(IPC1-7):C07J73/00 |
主分类号 |
A61K31/58 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|