发明名称 |
Process for producing (R)-styrene oxides |
摘要 |
The present invention provides a process for producing (R)-styrene oxides represented by the formula (1): <IMAGE> (1) wherein R1, R2, R3 and X are as defined in the specification, which comprises treating a mixture of (R)- and (S)-phenylhalogenomethylcarbinols with a lipase in the presence of a carboxylate to preferentially convert the (S)-phenylhalogenomethylcarbinols, and treating a mixture of the formed carbinol alkylates (3) and (R)-phenylhalogenomethylcarbinols with a base to cyclize the (R)-phenylhalogenomethylcarbinols, and also provides an industrially excellent process for producing (R)-styrene oxides (1) which comprises using a mixture enriched with (R)-phenylhalogenomethylcarbinols as the mixture of (R)- and (S)-phenylhalogenomethylcarbinols (2).
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申请公布号 |
US5717116(A) |
申请公布日期 |
1998.02.10 |
申请号 |
US19960624084 |
申请日期 |
1996.03.29 |
申请人 |
SUMIKA FINE CHEMICALS COMPANY, LIMITED |
发明人 |
SAITO, KENJI;KOMETANI, NORIO;FUJIWARA, AZUSA;YONEYOSHI, YUKIO;SUZUKAMO, GOHFU |
分类号 |
C07D301/26;C07D303/02;C12P7/62;C12P41/00;(IPC1-7):C07D301/24 |
主分类号 |
C07D301/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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