| 发明名称 |
Use of carbocation scavenger during oligonucleotide synthesis |
| 摘要 |
During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.
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| 申请公布号 |
US5714597(A) |
申请公布日期 |
1998.02.03 |
| 申请号 |
US19960613036 |
申请日期 |
1996.03.08 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
RAVIKUMAR, VASULINGA;ANDRADE, MARK;MULVEY, DENNIS;COLE, DOUGLAS L. |
| 分类号 |
C07H21/00;(IPC1-7):C07H1/00;C07H21/02;C07H21/04 |
主分类号 |
C07H21/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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