Novel benzimidazole, benzoxazole, and benzothiazole derivatives useful as interleukin 1beta inhibitors

摘要

Benzimidazole, benzoxazole and benzothiazole derivatives of formula (I), their isomers and salts are new. R1 = halo, OH, 1-6C alkoxy (optionally substituted by aryl), trihalomethyl, amino (optionally substituted by 1 or more optionally substituted alkyl or aryl groups), SH, 1-6C alkylthio, 1-6C trialkyl-ammonium, aryloxy, arylthio, aryl-sulphonyl, aryl-sulphonyloxy, 3-7C cycloalkyloxy or cycloalkylthio, or 6-8C bicyclo-alkyloxy or bicyclo-alkylthio (both optionally substituted by aryl); Ra, Rb = H or 1-6C alkyl; X = O, S, or NR; R = H or 1-6C alkyl; Y = (CH2)mZ(CH2)n; m, n = 0-2; Z = O, S, amino optionally substituted by alkyl, SO2, CHOH, CH2, or CH(CH2OH); and R2 = optionally substituted aryl.