摘要 |
PROBLEM TO BE SOLVED: To industrially advantageously produce the subject compound useful as an intermediate, etc., for an anti-HIV agent by reacting a trans-(±)-2 bromo-1-(acyloxy)indane in the presence of a hydroxy compound and a specific enzyme in an organic solvent and then separating the resultant product. SOLUTION: Trans-(±)-2-Bromo-1-(acyloxy) indanes represented by formula I [R1 is an alkyl, a (substituted)aryl or a (substituted)aralkyl] are reacted with a hydroxy compound represented by the formula R2 OH (R2 is H, a 1-12C alkyl or a 3-8C cyclic alkyl) in the presence of a lipase derived from a yeast fungus or its recombinant in an organic solvent to preferentially solvolyze either one of optical isomers of the (1R,2R)-isomer represented by formula II and the (1S,2S)-isomer represented by formula III. Thereby, a trans-(-)-(1R,2R)-, bromoindan-1-ol represented by formula IV or a trans-(+)-(1S,2S)-bromoindan-1-ol is obtained and the product is separated to afford the objective optically active compound at a low cost. |