发明名称 |
Method of predicting fetal membrane rupture based on pro-matrix metalloproteinase-9 (pro-mmp-9) |
摘要 |
Disclosed is a method of predicting the onset of fetal membrane rupture in a gestative female comprising the step of assaying a tissue or fluid sample of fetal membrane origin obtained from the female for the presence of pro-metalloproteinase-9 (pro-mmd-9). The presence of pro-mmd-9 in the sample is a positive indication of the onset of fetal membrane rupture. Also disclosed is a method of delaying the onset of female membrane rupture in a gestative female comprising the step of administering to the female an MMP-9 inhibitor in an amount effective to delay fetal membrane rupture. Further disclosed is a method of inducing labor in a gestative female comprising the administration of an MMP-9 activator or MMP-9 itself in an amount effective to induce fetal membrane rupture, and thus facilitate the onset of labor.
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申请公布号 |
US5698404(A) |
申请公布日期 |
1997.12.16 |
申请号 |
US19960727883 |
申请日期 |
1996.10.09 |
申请人 |
UNIVERSITY OF PENNSYLVANIA |
发明人 |
STRAUSS, III, JEROME FRANK;VADILLO-ORTEGA, FELIPE |
分类号 |
A61K31/165;A61K31/31;A61K31/5575;A61K38/00;A61K38/19;A61K38/48;A61K38/57;C07K16/40;C12Q1/37;G01N33/573;(IPC1-7):G01N33/53 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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