发明名称 |
ANTIGEN BINDING FRAGMENTS THAT SPECIFICALLY DETECT CANCER CELLS, NUCLEOTIDES ENCODING THE FRAGMENTS, AND USE THEREOF FOR THE PROPHYLAXIS AND DETECTION OF CANCERS |
摘要 |
The present invention relates to monoclonal antibody H11 and antigen binding fragments that specifically bind to the antigen recognized by H11, the C-antigen. The C-antigen is found specifically on neoplastic cells and not on normal cells. Also disclosed are polynucleotide and polypeptide derivatives based on H11, including single chain V region molecules and fusion proteins, and various pharmaceutical compositions. When administered to an individual, the H11 antibody is effective in diagnosing, localizing, and/or treating neoplasias. The invention further provides methods for treating a neoplastic disease, particularly melanoma, neuroblastoma, glioma, soft tissue sarcoma, and small cell lung carcinoma. Patients who are in remission as a result of traditional modes of cancer therapy may be treated with a composition of this invention in hopes of reducing the risk of recurrence. Patients may also be treated concurrently with the antibodies and traditional anti-neoplastic agents. |
申请公布号 |
WO9744461(A2) |
申请公布日期 |
1997.11.27 |
申请号 |
WO1997US08962 |
申请日期 |
1997.05.22 |
申请人 |
NOVOPHARM BIOTECH, INC.;DAN, MICHAEL, D.;MAITI, PRADIP, K.;KAPLAN, HOWARD, A. |
发明人 |
DAN, MICHAEL, D.;MAITI, PRADIP, K.;KAPLAN, HOWARD, A. |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K39/00;A61K39/395;A61K45/00;A61K47/48;A61K48/00;A61K51/10;A61P35/00;C07K16/30;C12N5/10;C12N15/13;C12N15/86;C12P21/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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