| 摘要 |
PROBLEM TO BE SOLVED: To obtain a fluorine-containing compound useful as a synthetic intermediate for a medicine, a chemical or a functional material, by carrying out the functional replacement reaction of an α-perfluoroalkylated alcohol derivative, which has been regarded to be difficult, in the presence of a specific compound. SOLUTION: A sulfonic acid ester of an α-perfluoroalkylated alcohol of formula I (R<1> and R<2> are each H, an alkyl, an aromatic group, an aralkyl, an alkenyl or R<1> and R<2> form a ring with an adjoining carbon atom; Rf is a perfluoroalkyl; R<3> is an alkyl, an aromatic group or a halogen) is reacted with a nucleophilic reagent of the formula HY [Y is Q<1> R<4> , Q<2> R<5> R<6> (Q<1> is O, S, selenium or tellurium; Q<2> is N, P or arsine; R<4> to R<6> are each H, alkyl, an aromatic group, etc.; R<5> and R<6> form a ring) in the presence of a basic substance to give a fluorine-containing compound of formula II. NaOH, KF, phenyllithium may be cited as the basic substance. For example, a compound of formula V is obtained from a compound of formula III and a compound of formula IV by using the method. |
