发明名称 |
OXYGEN SUBSTITUTED DERIVATIVES OF NUCLEOPHILE-NITRIC OXIDE ADDUCTS AS NITRIC OXIDE DONOR PRODRUGS |
摘要 |
<p>There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular disorders with the compounds. The active components of the pharmaceutical compositions are compounds of formula I <IMAGE> wherein R1 and R2 are independently chosen from straight chain and branched chain alkyl and olefinic groups, which may be unsubstituted or substituted; or R1 and R2 together with the nitrogen atom they are bonded to form a heterocyclic group; and R3 is a pharmaceutically acceptable organic group selected from alkyl and olefinic groups which may be unsubstituted or substituted, acyl, a sulfonyl, sulfinyl, sulfenyl, carbonate, or carbamate derivative; or R3 is a group of the formula-(CH2)nONN(O)NR1R2, wherein n is 2-8, and R1 and R2 are as described above. Novel compounds are disclosed wherein at least one of R1, R2 and R3 is an olefinic group or heteroatom-substituted straight or branched chain alkyl or olefinic group. Novel methods of synthesizing the compounds are also disclosed.</p> |
申请公布号 |
EP0605622(B1) |
申请公布日期 |
1997.11.12 |
申请号 |
EP19920921096 |
申请日期 |
1992.09.23 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KEEFER, LARRY, KAY;DUNAMS, TAMBRA, MARIE;SAAVEDRA, JOSEPH, EUCLID |
分类号 |
C07D295/22;A61K31/13;A61K31/135;A61K31/15;A61K31/40;A61K31/445;A61K31/451;A61K31/495;A61K31/535;A61K31/5375;A61K31/655;A61P9/12;C07C245/24;C07C291/08;C07C307/02;C07D211/98;C07D295/28;(IPC1-7):C07C245/24;C07D265/30;A61K31/00;C07D241/54;C07D207/50;A61K31/395;C07D205/00 |
主分类号 |
C07D295/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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