Novel taxoids preparation thereof and pharmaceutical compositions containing same

摘要

PCT No. PCT/FR96/00487 Sec. 371 Date Oct. 2, 1997 Sec. 102(e) Date Oct. 2, 1997 PCT Filed Apr. 1, 1996 PCT Pub. No. WO96/31493 PCT Pub. Date Oct. 10, 1996Novel taxoids of general formula (I), wherein R is a substituted alkyl radical or an alkenyl, alkynyl, cycloalkyl, optionally substituted cycloalkenyl or phenyl radical, or an aromatic 5- or 6-membered heterocyclic radical; and Z is a hydrogen atom or a radical of general formula (II), wherein R1 is an optionally substituted benzoyl, thenoyl or furoyl radical or a radical R2-O-CO, where R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl, or heterocycl radical, and R3 is an aromatic heterocyclic, alkyl, alkenyl, alkynyl cycloalkyl, phenyl or naphthyl radical. The novel products of general formula (I), wherein Z is a radical of general formula (II), have remarkable antitumoral activity.