发明名称 |
Cytokine designated 4-IBB ligand |
摘要 |
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.
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申请公布号 |
US5674704(A) |
申请公布日期 |
1997.10.07 |
申请号 |
US19940236918 |
申请日期 |
1994.05.06 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
GOODWIN, RAYMOND G.;SMITH, CRAIG A.;ALDERSON, MARK R. |
分类号 |
A61K38/00;C07K14/52;C07K14/715;C12N15/12;(IPC1-7):C12N15/12;C12N15/63;C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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