| 摘要 |
PROBLEM TO BE SOLVED: To safely obtain a phenylpiperazine compound useful as an intermediate for various medicines in high yield and quality without releasing toxic substances produced during its production into the environment. SOLUTION: This phenylpiperazine compound of formula I (R is H, nitro, amino, cyano, a 1-6C alkyl, aryl, 1-6C alkoxy, aryloxy, halogeno, hydroxyl, etc.; (n) is 1-3) is obtained by reaction of an aniline compound of formula II with a bis(2-halogenoethyl)amine hydrohalogenide, without releasing the latter out of the reaction system, in a solvent (e.g. methanol) in the presence of a sodium or potassium (bi)carbonate, tertiary organic amine and nitrogen-contg. heterocyclic compound at a temperature close to the boiling point of the solvent. The bis(2-halogenoethyl)amine hydrohalogenide is prepared by halogenating diethanolamine. |
